Formulation & Evaluation of Salbutamol Effervescent Tablets

Chronic Obstructive Pulmonary Disease (COPD) is one of the mostlong term pulmonary infection associated with difficulties in normal respiration process due to blocked airflow via bronchioles. Salbutamol is a commonly used bronchodilator that helps open the airways, but traditional oral tablets may work slowly because they take time to dissolve and absorb. This delay can be a problem for elderly patients or those who have trouble swallowing. This research aims to develop and test effervescent tablets containing Salbutamol to provide faster relief and easier administration for patients with COPD. Effervescent tablets dissolve quickly in water, forming a fizzy solution that is easy to swallow and allows for faster drug absorption. In this study, Salbutamol was combined with ingredients like sodium bicarbonate, citric acid, and tartaric acid using the wet granulation method. These ingredients were chosen for their ability to produce a fast- dissolving, stable, and effective tablet. The properties of Salbutamol, such as solubility and stability, were studied to ensure accurate dosage and proper function. The prepared tablets were tested for weight variation, thickness, hardness, friability, effervescence time, and disintegration time to confirm quality and performance. Some tablets were also designed to float in the stomach to improve absorption over time. The results showed that the effervescent tablets delivered Salbutamol quickly and effectively, offering a useful alternative for treating COPD symptoms. This type of tablet can improve patient comfort, compliance, and treatment outcomes, especially for those who have difficulty swallowing regular tablets.