CervicalMethDx: A Precision DNA Methylation Test to Identify Risk of High-Grade Intraepithelial Lesions in Cervical Cancer Screening Algorithms
The CervicalMethDx test integrates DNA methylation analysis and machine learning to improve early detection of high-grade cervical lesions (high-grade squamous intraepithelial lesions), offering a noninvasive, cost-effective screening tool. Enhanced risk stratification and overtreatment reduction expand equitable access to precision prevention programs. Further validation will clarify CervicalMethDx's alignment with global cervical cancer prevention strategies.
Authors
- Josefina Romaguera (ORCID: https://orcid.org/0000-0001-5403-9160)
- Ashley Ramos-Lopez
- Bruce J. Trock (ORCID: https://orcid.org/0000-0003-3529-9295)
- Teresa Díaz-Montes (ORCID: https://orcid.org/0000-0003-0881-3236)
- Fernando T. Zamunér (ORCID: https://orcid.org/0000-0002-6106-4361)
- Laura Palmieri (ORCID: https://orcid.org/0000-0002-2998-8679)
- Amanda García-Negrón
- Keerthana Gosala
- Eli Winkler
- Rafael Guerrero‐Preston (ORCID: https://orcid.org/0000-0002-6639-6488)
- Dieila Giomo de Lima (ORCID: https://orcid.org/0000-0002-5163-6047)
- Ana Purcell‐Wiltz (ORCID: https://orcid.org/0009-0009-7264-460X)
- Mariana Brait (ORCID: https://orcid.org/0000-0002-1652-8921)
- David Sidransky
- Yash Prashar
Institutions
- MetLife (United States) (US)
- Mercy Medical Center (US)
- Johns Hopkins University (US)
- University of Puerto Rico System (PR)
- BirdLife International (KE)
- Johns Hopkins Medicine (US)
- Hospital Israelita Albert Einstein (BR)
- Brazilian Biosciences National Laboratory (BR)
- Mercy Medical Center (US)
Publication Details
- Journal
- Cancer Prevention Research
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1158/1940-6207.capr-25-0029
- Citations
- 1
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Johns Hopkins University
- Ascentage Pharma
- Puerto Rico Science, Technology and Research Trust
- National Institutes of Health
- National Cancer Institute
- National Institute on Minority Health and Health Disparities