Evaluation and Correlation of 17β-Estradiol in Blood and Estrogen Receptor α (ERα) and Estrogen Receptor β(ER β) in Tissue of Oral Squamous Cell Carcinoma

The levels of E2 can be used as a marker in predicting the progression of disease from normal tissue not exposed to tobacco to normal tissue exposed to tobacco to premalignant to OSCC. The ERα in tissue is positively correlated with the increased levels of E2 in serum, so ERα expression in tissue along with E2 in serum could be used to identify the subsets of patients with higher risk of developing OSCC, especially those subjects with established tobacco habit but no appreciable change in oral mucosa.