Apolipoprotein E selectively supports gammaherpesvirus replication in macrophages
ApoE is an apolipoprotein that mediates lipid transport and exchange between tissues and the circulation. ApoE differentially affects several virus families, but its role in gammaherpesvirus infection remains unknown. Here, we show that ApoE supported lytic gammaherpesvirus replication in primary macrophages and that infected macrophages increased expression of ApoE in an interferon-dependent manner. However, ApoE expression did not affect viral latency <i>in vivo</i>, implying a novel viral life cycle-specific proviral role for ApoE in gammaherpesvirus infection.
Authors
- Xander Bradeen
- Matthew Brown (ORCID: https://orcid.org/0000-0001-5832-4073)
- Vera L. Tarakanova (ORCID: https://orcid.org/0000-0002-9499-088X)
- Philip T. Lange (ORCID: https://orcid.org/0000-0003-0745-5545)
- Daisy Sahoo (ORCID: https://orcid.org/0000-0001-5210-6497)
- Damon L. Schmalzriedt
- C. A. Aurubin
- Jordan Bobek
- Cade R. Rahlf
Institutions
- Medical College of Wisconsin (US)
Publication Details
- Journal
- Journal of Virology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1128/jvi.00480-25
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Instituto Nacional de Cancerología
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases