The influence of genetics on the endocannabinoid system gene expression and relevance for targeting reproductive conditions
This is the first study to investigate the effects of genetic variants on the ECS gene transcription and indicates genetic variants have significant influence that are unique to each tissue. Our results highlight the effect of individual variation and the impact endocannabinoid based therapies may have on different tissue and physiological systems.
Authors
- Jacqueline F. Donoghue (ORCID: https://orcid.org/0000-0003-1370-2469)
- Keisuke Tanaka (ORCID: https://orcid.org/0000-0001-8958-0731)
- Peter A. W. Rogers (ORCID: https://orcid.org/0000-0002-7399-8997)
- Sarah J. Holdsworth‐Carson (ORCID: https://orcid.org/0000-0002-3533-0486)
- Grant W. Montgomery (ORCID: https://orcid.org/0000-0002-4140-8139)
- Wan Tinn Teh (ORCID: https://orcid.org/0000-0001-9808-1141)
- Akwasi Amoako (ORCID: https://orcid.org/0000-0002-9428-650X)
- Sally Mortlock (ORCID: https://orcid.org/0000-0003-2327-9465)
- Brett McKinnon (ORCID: https://orcid.org/0000-0002-9881-1252)
Institutions
- University of Bern (CH)
- Royal Women's Hospital (AU)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- Royal Brisbane and Women's Hospital (AU)
- Epworth Hospital (AU)
- Endometriosis UK (GB)
Publication Details
- Journal
- Journal of Cannabis Research
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1186/s42238-025-00275-x
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council
- National Health and Medical Research Council