Integrated multi-omics reveals different host crosstalk of atopic dermatitis-enriched Bifidobacterium longum Strains
The infant gut microbiome is essential for long-term health and is linked to atopic dermatitis (AD), although the underlying mechanisms are not fully understood. This study investigated gut microbiome-host interactions in 31 infants with AD and 29 healthy controls using multi-omics approaches, including metagenomic, host transcriptomic, and metabolomic analyses. Microbial diversity was significantly altered in AD, with Bifidobacterium longum and Clostridium innocuum associated with these changes. At the strain-level, only B. longum differed significantly between groups, with pangenome analyses identifying genetic variations potentially affecting amino acid and lipid metabolites. Notably, B. longum subclade I, which was more prevalent in healthy controls, correlated with host transcriptomic pathways involved in phosphatidylinositol 3-kinase-AKT signaling and neuroactive ligand-receptor pathways, as well as specific metabolites, including tetrahydrocortisol and ornithine. These findings highlight the role of B. longum strain-level variation in infants, offering new insights into microbiome-host interactions related to AD.
Authors
- Bong Soo Kim (ORCID: https://orcid.org/0000-0003-1243-8280)
- Hyun Ju Yoo (ORCID: https://orcid.org/0000-0003-2617-444X)
- Yun Kyung Lee (ORCID: https://orcid.org/0000-0003-3437-5137)
- Soo‐Jong Hong (ORCID: https://orcid.org/0000-0003-1409-2113)
- Yoon Mee Park (ORCID: https://orcid.org/0000-0003-4760-9262)
- Hoon Je Seong (ORCID: https://orcid.org/0000-0002-9697-2677)
- Myung Hee Nam
- Taeyune Kim (ORCID: https://orcid.org/0000-0002-5407-7500)
- Dong‐Woo Lee (ORCID: https://orcid.org/0000-0002-2272-8321)
- So‐Yeon Lee (ORCID: https://orcid.org/0000-0002-2499-0702)
- Jeong‐Hyun Kim (ORCID: https://orcid.org/0000-0003-4879-0075)
- Sun Mi Yoon
Institutions
- Ulsan College (KR)
- Kunsan National University (KR)
- Ewha Womans University (KR)
- Hallym University (KR)
- Yonsei University (KR)
- Soonchunhyang University (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
- Digital Science (United States) (US)
- Macrogen (South Korea) (KR)
- Korea Basic Science Institute (KR)
Publication Details
- Journal
- npj Biofilms and Microbiomes
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1038/s41522-025-00714-w
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Research Foundation
- Ministry of Environment
- National Research Foundation of Korea
- Ministry of Education, India
- Ministry of Science and ICT, South Korea
- Centers for Disease Control and Prevention
- Korea National Institute of Health
- Korea Environmental Industry and Technology Institute