Dual-Function Monoliths Prepared by Supercritical CO <sub>2</sub> Foaming to Control <i>Aedes aegypti</i>
Aedes aegypti, a vector of dengue, yellow fever, chikungunya, and Zika, is a major public health threat in Brazil and tropical countries; now, it is also in Europe. Tea tree oil (TTO) and curcuminoids (Cur) have shown larvicidal and repellent effects against A. aegypti. This study developed porous poly(ε-caprolactone) (PCL) monoliths with Pluronic F-68 (Plu) using the supercritical CO2 foaming method (SFM) for controlled TTO and Cur release. SFM conditions and monolith compositions were varied to modify monolith properties. Bioactive agents’ release was tested in water and air (gravimetric and wind tunnel) with volatiles persisting for over 15 days. Larvicidal and repellent tests were performed on A. aegypti colonies. This study prospects the TTO- and TTO-Cur-loaded PCL:Plu monoliths as emerging and sustainable biomaterials for mosquito control, acting as both larvicidal and insect repellents.
Authors
- Gabriel Bezerra Faierstein (ORCID: https://orcid.org/0000-0002-1663-7642)
- Glaucia R. M. Burin (ORCID: https://orcid.org/0000-0003-3036-6372)
- Fábio Rocha Formiga (ORCID: https://orcid.org/0000-0003-1553-0533)
- José Miranda (ORCID: https://orcid.org/0000-0002-9136-1316)
- Vinícius C. Pires (ORCID: https://orcid.org/0000-0003-2387-9794)
- Elaine Christine de Magalhães Cabral Albuquerque (ORCID: https://orcid.org/0000-0002-3472-9129)
- Sílvio A.B. Vieira de Melo (ORCID: https://orcid.org/0000-0002-8617-3724)
- Rosângela Maria Rodrigues Barbosa (ORCID: https://orcid.org/0000-0002-1171-598X)
- Mara E.M. Braga (ORCID: https://orcid.org/0000-0003-4142-4021)
- Hermínio C. de Sousa (ORCID: https://orcid.org/0000-0002-2629-7805)
Institutions
- Universidade Federal da Bahia (BR)
- Ceres (US)
- Hospital de Magalhães Lemos (PT)
- Fundação Oswaldo Cruz (BR)
- University of Coimbra (PT)
Publication Details
- Journal
- ACS Sustainable Chemistry & Engineering
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1021/acssuschemeng.5c01126
- Primary Topic
- Polymer Foaming and Composites
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado da Bahia
- Fundação Oswaldo Cruz
- Fundação para a Ciência e a Tecnologia