Antibiotic stewardship in hematological patients with Escherichia coli and Klebsiella pneumoniae bloodstream infections: evaluating short-course and carbapenem-sparing strategies
In conclusion, short-course antibiotic therapy is as effective as prolonged therapy for treating E. coli and K. pneumoniae BSI in hematological patients. Similarly, carbapenem-sparing regimens are non-inferior to carbapenem-based regimens. These findings highlight the potential for optimizing antibiotic use, but further validation through randomized controlled trials is warranted.
Authors
- Mingzhe Han (ORCID: https://orcid.org/0000-0002-1720-6799)
- Qingsong Lin (ORCID: https://orcid.org/0000-0001-6082-8684)
- Xiaofan Zhu (ORCID: https://orcid.org/0000-0002-2572-6495)
- Sizhou Feng (ORCID: https://orcid.org/0000-0001-5304-3301)
- Erlie Jiang (ORCID: https://orcid.org/0000-0003-0237-6063)
- Yuqing Cui
- Zhijian Xiao (ORCID: https://orcid.org/0000-0002-1099-4489)
- Yuping Fan (ORCID: https://orcid.org/0000-0003-3929-132X)
- Xin Chen (ORCID: https://orcid.org/0000-0001-7706-4166)
- Sisi Zhen
- Jianxiang Wang (ORCID: https://orcid.org/0000-0001-9437-9151)
- Xiaomeng Feng
- Yizhou Zheng (ORCID: https://orcid.org/0000-0001-5939-7549)
- Fengkui Zhang (ORCID: https://orcid.org/0000-0002-2553-5998)
- Jieru Wang (ORCID: https://orcid.org/0000-0002-7984-4550)
- Ling Pan
- Yingchang Mi
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Institute of Hematology & Blood Diseases Hospital (CN)
Publication Details
- Journal
- Annals of Clinical Microbiology and Antimicrobials
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1186/s12941-025-00801-y
- Primary Topic
- Neutropenia and Cancer Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beijing Xisike Clinical Oncology Research Foundation
- Chinese Academy of Medical Sciences
- Tianjin Science and Technology Committee
- National Science and Technology Major Project