RNA Sequencing Identifies WT1 Overexpression as a Predictor of Poor Outcomes in Acute Myeloid Leukemia
By integrating RNA sequencing with targeted validation, this study highlights WT1 expression as a critical biomarker for AML diagnosis, prognosis, and treatment response. The findings suggest that WT1 expression may serve as a valuable tool for monitoring disease status, risk stratification, and guiding treatment decisions in AML, with potential applications for WT1-targeted precision therapies.
Authors
- Sameer Bakhshi (ORCID: https://orcid.org/0000-0001-9367-4407)
- Amar Ranjan (ORCID: https://orcid.org/0000-0003-1123-338X)
- Somorjit Singh Ningombam (ORCID: https://orcid.org/0000-0002-7282-4207)
- Mohammad Shadab Ali (ORCID: https://orcid.org/0000-0002-0205-1456)
- Harsh Goel (ORCID: https://orcid.org/0000-0003-3904-7343)
- Anita Chopra (ORCID: https://orcid.org/0000-0002-0238-8702)
- Jagdish Prasad Meena (ORCID: https://orcid.org/0000-0001-6024-9762)
- Jay Singh (ORCID: https://orcid.org/0000-0002-3793-0450)
- Pranay Tanwar (ORCID: https://orcid.org/0000-0002-2357-976X)
- Avanish Pandey (ORCID: https://orcid.org/0000-0003-3014-4913)
- Harshita Makkar
- Rakesh Kumar (ORCID: https://orcid.org/0000-0002-0741-3663)
- Showket Hussain (ORCID: https://orcid.org/0000-0003-1456-9217)
- Atul Batra (ORCID: https://orcid.org/0000-0002-1934-8408)
- Ranjit Kumar Sahoo (ORCID: https://orcid.org/0000-0002-4130-724X)
- Aditya Gupta (ORCID: https://orcid.org/0000-0002-3730-8944)
- Rahul Kumar (ORCID: https://orcid.org/0000-0001-6585-6780)
- Ganesh Kumar Viswanathan (ORCID: https://orcid.org/0000-0003-4793-6829)
- Abhimanyu Kumar Jha (ORCID: https://orcid.org/0000-0002-6798-2825)
- Farhat Naz (ORCID: https://orcid.org/0000-0002-1445-5458)
- Goura Kishor Rath
Institutions
- Galgotias University (IN)
- National Institute of Cancer Prevention and Research (IN)
- DR. B.R.A. Institute Rotary Cancer Hospital (IN)
- All India Institute of Medical Sciences (IN)
Publication Details
- Journal
- Cancers
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3390/cancers17111818
- Citations
- 1
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- All-India Institute of Medical Sciences