Clinical Significance of Hypokalemia in Blunt Liver Trauma: Preliminary Findings in a Retrospective Cohort Study of 164 Patients

<b>Background:</b> The clinical significance of serum potassium levels at admission in patients with blunt hepatic trauma remains insufficiently defined. This study aimed to evaluate the prevalence and prognostic value of admission hypokalemia in this patient population. <b>Methods:</b> We conducted a retrospective analysis of 164 patients with radiologically confirmed blunt liver trauma admitted between 2016 and 2023. Preoperative, intraoperative, and postoperative data were collected to assess the association between serum potassium levels and trauma severity (AAST grade-American Association for the Surgery of Trauma, ISS-Injury Severity Score), in-hospital morbidity, mortality, and length of stay. Univariate and multivariate analyses were performed, including checks for normality and multicollinearity. <b>Results:</b> Serum potassium levels showed a significant positive correlation with age (<i>p</i> = 0.0064), and an inverse correlation with liver injury severity (AAST grade; <i>p</i> = 0.01). Lower potassium levels were associated with longer hospital stays (<i>p</i> = 0.0459) and higher morbidity (<i>p</i> = 0.022). In multivariate analysis, only age (<i>p</i> = 0.036) and AAST grade (<i>p</i> = 0.014) were independent predictors of serum potassium concentration. Potassium levels were not independently associated with mortality. <b>Conclusions:</b> Admission hypokalemia is a common finding in blunt liver trauma and correlates with injury severity and adverse clinical outcomes. Potassium concentration may serve as a readily available, low-cost biomarker for early risk stratification in these patients. Further prospective studies are warranted to confirm its prognostic utility.

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Journal
Journal of Clinical Medicine
Published
2025-05-29
DOI
https://doi.org/10.3390/jcm14113835
Primary Topic
Abdominal Trauma and Injuries
Type
article
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0.00

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article

Clinical Significance of Hypokalemia in Blunt Liver Trauma: Preliminary Findings in a Retrospective Cohort Study of 164 Patients

Eleonora Cianci, L Simonelli, Simona Meneghini, Pierfrancesco Lapolla et al.
Journal of Clinical Medicine
Abdominal Trauma and Injuries
article

Clinical Significance of Hypokalemia in Blunt Liver Trauma: Preliminary Findings in a Retrospective Cohort Study of 164 Patients

Eleonora Cianci, L Simonelli, Simona Meneghini, Pierfrancesco Lapolla, Marco La Torre, Roberto Cirocchi, Emilio Gentile Warschauer, Giulia Duranti, Bruno Cirillo, Andrea Mingoli, Gioia Brachini
article en

Abstract

<b>Background:</b> The clinical significance of serum potassium levels at admission in patients with blunt hepatic trauma remains insufficiently defined. This study aimed to evaluate the prevalence and prognostic value of admission hypokalemia in this patient population. <b>Methods:</b> We conducted a retrospective analysis of 164 patients with radiologically confirmed blunt liver trauma admitted between 2016 and 2023. Preoperative, intraoperative, and postoperative data were collected to assess the association between serum potassium levels and trauma severity (AAST grade-American Association for the Surgery of Trauma, ISS-Injury Severity Score), in-hospital morbidity, mortality, and length of stay. Univariate and multivariate analyses were performed, including checks for normality and multicollinearity. <b>Results:</b> Serum potassium levels showed a significant positive correlation with age (<i>p</i> = 0.0064), and an inverse correlation with liver injury severity (AAST grade; <i>p</i> = 0.01). Lower potassium levels were associated with longer hospital stays (<i>p</i> = 0.0459) and higher morbidity (<i>p</i> = 0.022). In multivariate analysis, only age (<i>p</i> = 0.036) and AAST grade (<i>p</i> = 0.014) were independent predictors of serum potassium concentration. Potassium levels were not independently associated with mortality. <b>Conclusions:</b> Admission hypokalemia is a common finding in blunt liver trauma and correlates with injury severity and adverse clinical outcomes. Potassium concentration may serve as a readily available, low-cost biomarker for early risk stratification in these patients. Further prospective studies are warranted to confirm its prognostic utility.

Journal of Clinical MedicineVol. 14(11)
University of Perugia (IT), University of Oxford (GB), Ospedale San Pietro Fatebenefratelli (IT), Sapienza University of Rome (IT)
Sapienza Università di Roma
Openalex Percentile: Top 79%
Abdominal Trauma and Injuries
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