Dolutegravir Derivatives Alleviate LPS-Induced Microglial Inflammation by Suppressing STAT1/3 Nuclear Translocation
Compound <b>4k</b> exerts significant anti-microglial inflammatory effects by modulating the STAT signaling pathway to alleviate synaptic defects, which offers promising avenues for developing innovative anti-microglial inflammatory treatment strategies.
Authors
- Longfei Mao (ORCID: https://orcid.org/0000-0003-0759-0501)
- Xixi Hou
- Yimian Wang
- Lizeng Peng
- Lan Wang (ORCID: https://orcid.org/0000-0002-9972-7597)
- Xiaoting Zhang (ORCID: https://orcid.org/0009-0006-6751-9722)
Institutions
- Henan University of Science and Technology (CN)
- Institute of Agro-Products Processing Science and Technology (CN)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/dddt.s520724
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00