The novelty of profilin 2 in regulating pyruvate kinase M2 nuclear translocation and promoting tumor angiogenesis in lung adenocarcinoma
Our study revealed oncogene PFN2 promoted tumor angiogenesis in LUAD through regulating PKM2 nuclear translocation, providing novel molecular therapy targets for LUAD treatment.
Authors
- Qi Wang (ORCID: https://orcid.org/0000-0001-7155-8878)
- Yingyan Wang (ORCID: https://orcid.org/0000-0001-7869-352X)
- Xiaohui Du (ORCID: https://orcid.org/0000-0001-6788-8997)
- Shuang Wen (ORCID: https://orcid.org/0000-0002-5830-8038)
- Yanbin Kuang (ORCID: https://orcid.org/0000-0003-3041-7854)
- Mingxin Xu (ORCID: https://orcid.org/0009-0002-5228-3623)
- Chi Ma (ORCID: https://orcid.org/0000-0002-4302-9079)
- Hui Zhao (ORCID: https://orcid.org/0000-0003-1614-1994)
- Mengyun Li (ORCID: https://orcid.org/0009-0008-3488-7240)
- Peipei He
Institutions
- Shanghai Jiao Tong University (CN)
- Dalian Medical University (CN)
- Shanghai Chest Hospital (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Yili Friendship Hospital (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1186/s12931-025-03281-y
- Citations
- 2
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Liaoning Revitalization Talents Program