Fiber optic biosensor utilizing magneto-optic effect in hollow-core anti-resonant optic fiber

A biosensor that tracks the wavelength shift of transmission spectra is proposed for immunodetection. The property of controllable refractive index of magnetic nanoparticle solution (magnetic fluid) is exploited as a marker for the immunosensor and as a sensitive medium for the light fiber core. Increased magnetic particle size due to target-specific binding results in a localized shift in the peak of the measured transmission spectrum due to a change in the refractive index in the fibrous core. The binding between biomolecules was modeled with magnetic beads bound to affinities and biotin-polystyrene microspheres. Changing the substances bound to the magnetic nanoparticles enables the detection of other biomolecules. Biotin-polystyrene microspheres and magnetic beads attached to affinity were used to simulate the interaction between biomolecules. Other biomolecules can be detected by altering the materials attached to the magnetic nanoparticles. Our suggested approach offers a fresh concept for tiny and portable immunobiosensors.