Sleep patterns and DNA methylation age acceleration in middle-aged and older Chinese adults
In this cohort study, individuals with a higher sleep score had a slower DNAm AA, particularly in older adults. A slower DunedinPACE partially explained the association between higher sleep scores and lower all-cause mortality risk. These findings suggest that adopting healthy sleep patterns may promote healthy aging and further benefit premature mortality prevention, highlighting the value of sleep patterns as a potential tool for clinical management in aging.
Authors
- Ziwei Zhu (ORCID: https://orcid.org/0000-0002-3990-4774)
- Junrui Lyu (ORCID: https://orcid.org/0000-0002-4317-8875)
- Chaolong Wang (ORCID: https://orcid.org/0000-0003-3945-1012)
- Lue Zhou (ORCID: https://orcid.org/0000-0003-3658-3810)
- Fuchao Chen (ORCID: https://orcid.org/0000-0001-9738-6744)
- Tangchun Wu (ORCID: https://orcid.org/0000-0001-9931-5106)
- Tingyue Diao
- Xiaomin Zhang (ORCID: https://orcid.org/0000-0003-3877-5242)
- Kang Liu
- Qiu-Hong Wang (ORCID: https://orcid.org/0000-0003-3472-5037)
- Handong Yang (ORCID: https://orcid.org/0000-0003-0550-362X)
- Weijun Qin (ORCID: https://orcid.org/0009-0000-4794-3565)
Institutions
- Dongfeng General Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1186/s13148-025-01898-w
- Citations
- 2
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.24
Funders
- National Natural Science Foundation of China