Differential MYC Phosphorylation Drives the Divergent Cholangiocyte Response to Stress
MYC phosphorylation promotes either cholangiocyte proliferation or senescence. The results reveal kinase mediators of cholangiocyte fate and identify MYC as a stress-responsive "molecular switch."
Authors
- Gregory James Gores (ORCID: https://orcid.org/0000-0003-3151-009X)
- Nicholas F. LaRusso (ORCID: https://orcid.org/0000-0003-3266-0831)
- Patrick L. Splinter
- Steven P. O’Hara (ORCID: https://orcid.org/0000-0002-0480-5450)
- Antonia Felzen (ORCID: https://orcid.org/0000-0003-0326-9622)
- C. Alexander Turner
- Olivia Morgenthaler (ORCID: https://orcid.org/0000-0003-1217-0309)
Institutions
- Mayo Clinic (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101547
- Citations
- 2
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.64
Funders
- National Institute of Diabetes and Digestive and Kidney Diseases