Micronutrient antioxidant supplementation alleviates valproic acid-induced oxidative stress and male infertility via the NRF2/HO-1 pathway
Micronutrient antioxidants effectively reduce VPA-induced oxidative stress and improve male fertility. These results suggest that antioxidant supplementation could be a promising strategy to mitigate oxidative damage and enhance fertility in individuals undergoing VPA therapy.
Authors
- Bing Wan
- Muhammad Arif Asghar (ORCID: https://orcid.org/0000-0002-3220-8418)
- Yuanyuan Yang (ORCID: https://orcid.org/0000-0001-8606-079X)
- Qinjian Zhao (ORCID: https://orcid.org/0000-0002-6297-9969)
- Lu Li (ORCID: https://orcid.org/0000-0002-2299-6588)
- Shixin Tang (ORCID: https://orcid.org/0009-0005-0695-0968)
- Long Chu (ORCID: https://orcid.org/0000-0001-7842-7491)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-1340-646X)
- Qian Zhang (ORCID: https://orcid.org/0000-0001-8648-6467)
- Xiao Zhang (ORCID: https://orcid.org/0009-0001-2733-3898)
- Hang Han
Institutions
- Chongqing University (CN)
- Chongqing Public Health Medical Center (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1016/j.redox.2025.103685
- Citations
- 4
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 13.98
Funders
- China Scholarship Council