Unveiling the Therapeutic Potential of Baicalin in Intervertebral Disc Degeneration: Integrative Bulk and Single-Cell Transcriptome Analysis with Experimental Validation of PANoptosis Inhibition
Our findings reveal a critical role of PANoptosis in IVDD progression and demonstrate that baicalin alleviates disc degeneration by inhibiting PANoptosis. This study provides novel insights into PANoptosis as a promising therapeutic target for IVDD.
Authors
- Weiye Cai (ORCID: https://orcid.org/0000-0001-5839-1540)
- Zhangchao Wei
- Daqian Zhou
- Silong Gao (ORCID: https://orcid.org/0000-0002-7212-3822)
- Xiaoqiang Wang (ORCID: https://orcid.org/0000-0002-1441-0460)
- Chao Song (ORCID: https://orcid.org/0000-0003-0611-4298)
- Jiale Lv
- X. H. Shan
Institutions
- Southwest Medical University (CN)
- First Affiliated Hospital of Sichuan Medical University (CN)
- Suzhou Traditional Chinese Medicine Hospital (CN)
- Second People’s Hospital of Yibin (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/jir.s519179
- Citations
- 4
- Primary Topic
- Biological Activity of Diterpenoids and Biflavonoids
- Type
- article
- Field-Weighted Citation Impact
- 3.22