Mitochondrial alanyl-tRNA synthetase 2 mediates histone lactylation to promote ferroptosis in intestinal ischemia-reperfusion injury
The elevation of AARS2 during IIR led to cell ferroptosis <i>via</i> epigenetically upregulating the expression of ACSL4. Our findings presented AARS2 as a promising therapeutic target for IIR.
Authors
- Sanxiong Huang (ORCID: https://orcid.org/0000-0003-0568-386X)
- Zhuo Pan (ORCID: https://orcid.org/0000-0002-3864-2274)
- Wei Dong
- Mingkuan Qin
Institutions
- Third People's Hospital of Huzhou (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Surgery
- Published
- 2025-05-29
- DOI
- https://doi.org/10.4240/wjgs.v17.i6.106777
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 6.07