Spatial discovery of pyrotinib overcoming HER2-positive breast cancer resistance by breaking fibroblast-induced immune barriers
Spatial organization of cellular interactions in the tumor microenvironment (TME) provides insights into prognosis beyond pathological subtypes. The role of NeoPICD in disruption of fibroblast barriers and enhancement of immune cell function suggests therapeutic advantages in overcoming resistance to anti-HER2 therapies. This research offers new strategies for precision treatment of locally advanced HER2-positive breast cancer.
Authors
- Hanwen Hu (ORCID: https://orcid.org/0009-0003-8831-2948)
- Ouchen Wang (ORCID: https://orcid.org/0000-0001-5230-379X)
- Zhongmin Lin
- Qiongying Zhang
- Chenghui Yang (ORCID: https://orcid.org/0000-0001-9040-7047)
- Guohong Ren (ORCID: https://orcid.org/0000-0001-9553-5785)
- Zhen Wang (ORCID: https://orcid.org/0009-0009-3684-1200)
- Anqi Zhang (ORCID: https://orcid.org/0000-0003-0142-0106)
- Xia Li (ORCID: https://orcid.org/0000-0002-9794-2648)
- Yiying Xu (ORCID: https://orcid.org/0000-0003-1645-4165)
- Pu Cheng (ORCID: https://orcid.org/0000-0002-8687-3368)
- Zhiqiang Ye (ORCID: https://orcid.org/0000-0002-5722-3518)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Quzhou City People's Hospital (CN)
- Quzhou University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Drug Resistance Updates
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1016/j.drup.2025.101261
- Citations
- 3
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Wenzhou Medical University
- National Natural Science Foundation of China
- Medical Science and Technology Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province