MFAP4 Deficiency Attenuates Liver Fibrosis by Regulating Hepatic Stellate Cell Fate Through Inhibition of the FAK/PI3K/NFκB Signaling Pathway
MFAP4 governs HSCs activation and apoptosis resistance via integrin αvβ3-dependent FAK/PI3K/NFκB signaling. Targeting MFAP4 mitigates fibrosis by altering HSCs fate.
Authors
- Wang Zhang (ORCID: https://orcid.org/0000-0002-8438-6718)
- Linxiang Liu (ORCID: https://orcid.org/0000-0002-5691-486X)
- Yuan Nie (ORCID: https://orcid.org/0000-0001-7367-2359)
- Peng Chen (ORCID: https://orcid.org/0000-0002-2215-214X)
- Bimin Li (ORCID: https://orcid.org/0000-0001-7099-0343)
- Xuan Zhu (ORCID: https://orcid.org/0009-0003-8854-831X)
- Yue Zhang (ORCID: https://orcid.org/0000-0003-1514-2303)
- Chenkai Huang (ORCID: https://orcid.org/0000-0003-3755-5133)
Institutions
- First Affiliated Hospital of Jiangxi Medical College (CN)
- University of South China (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101548
- Citations
- 4
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 5.29
Funders
- National Natural Science Foundation of China