CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer
CARM1 mediates MAP2K4 activation and cross-talk with PI3K/AKT signaling, providing potential combination approaches for treating triple-negative breast cancer and explains the paradoxical role of MAP2K4 in ER+ and triple-negative breast cancer.
Authors
- Christopher J. Fry
- M Ma (ORCID: https://orcid.org/0000-0002-3529-0330)
- Megan S. Bacabac (ORCID: https://orcid.org/0000-0002-6332-6636)
- Yidan Wang (ORCID: https://orcid.org/0000-0002-1417-8059)
- Shulin Li (ORCID: https://orcid.org/0000-0001-5657-4183)
- Menggang Yu (ORCID: https://orcid.org/0000-0002-7904-3155)
- Wei Xu (ORCID: https://orcid.org/0000-0003-3808-0045)
- Aussie Suzuki (ORCID: https://orcid.org/0000-0001-7390-5116)
- Eui‐Jun Kim (ORCID: https://orcid.org/0000-0002-8475-5229)
- Jingjing Zhou (ORCID: https://orcid.org/0000-0002-7019-6825)
- Peng Liu (ORCID: https://orcid.org/0000-0001-5655-2259)
- Lingjun Li (ORCID: https://orcid.org/0000-0003-0056-3869)
- Jordan R. Hoffman
- Yulin Chen (ORCID: https://orcid.org/0009-0009-5703-7991)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- University of Wisconsin–Madison (US)
- University of Michigan (US)
- University of Wisconsin Carbone Cancer Center (US)
- Cell Signaling Technology (United States) (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3476
- Citations
- 2
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.61