Single-Nucleus and Bulk RNA Sequencing Reveals the Involvement of Natural Killer and CD8+ T Cells in the Progression of Androgenetic Alopecia
These findings collectively implicate NK and CD8<sup>+</sup> T cell infiltration as drivers of inflammatory exacerbation in AGA. By blocking IL-15 signaling-mediated immune activation may be an innovative therapeutic approach to promote hair regeneration in AGA patients.
Authors
- Shijun Shan (ORCID: https://orcid.org/0000-0003-2339-5466)
- Leiwei Jiang (ORCID: https://orcid.org/0009-0002-4603-0056)
- Haijing Fu
- Wumei Zhao
Institutions
- Zhejiang Normal University (CN)
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- The First People's Hospital of Guiyang (CN)
- Guizhou Provincial People's Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/jir.s522458
- Citations
- 3
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Natural Science Foundation of China