Randomized controlled trial reporting guidelines should be updated to include information on subsequent treatments

This paper highlights the urgent need to update randomized controlled trial reporting guidelines to include consistent and detailed data on subsequent treatments, particularly in oncology, where postprogression therapies significantly influence overall survival and cost‐effectiveness assessments. Drawing on our experience as an External Assessment Group and National Institute for Health and Care Excellence Committee members, a systematic review of renal cell carcinoma trials and broader regulatory guidance, we advocate for standardized reporting of subsequent treatment types, timing, and durations to enhance the reliability of health technology assessments and support more informed decision‐making.

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Publication Details

Journal
Cancer
Published
2025-05-29
DOI
https://doi.org/10.1002/cncr.35922
Citations
1
Primary Topic
Health Systems, Economic Evaluations, Quality of Life
Type
article
Field-Weighted Citation Impact
3.13
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article

Randomized controlled trial reporting guidelines should be updated to include information on subsequent treatments

Dawn Lee, Gina Torres
1 citations
Cancer
Health Systems, Economic Evaluations, Quality of Life
3.13
article

Randomized controlled trial reporting guidelines should be updated to include information on subsequent treatments

Dawn Lee, Gina Torres
article en
1 citations

Abstract

This paper highlights the urgent need to update randomized controlled trial reporting guidelines to include consistent and detailed data on subsequent treatments, particularly in oncology, where postprogression therapies significantly influence overall survival and cost‐effectiveness assessments. Drawing on our experience as an External Assessment Group and National Institute for Health and Care Excellence Committee members, a systematic review of renal cell carcinoma trials and broader regulatory guidance, we advocate for standardized reporting of subsequent treatment types, timing, and durations to enhance the reliability of health technology assessments and support more informed decision‐making.

CancerVol. 131(11)
University of Exeter (GB)
Peace, Justice and strong institutions
Openalex Percentile: Top 8%
Health Systems, Economic Evaluations, Quality of Life
3.13
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