FAT-SOLUBLE ANTIOXIDANT VITAMINS IN FEMALE AND MALE REPRODUCTION (REVIEW)

Introduction. According to data provided in a WHO report published on April 4, 2023, about 17.5% of the adult population or every sixth person in the world suffers from infertility. The problem of infertility does not have regional, national and social manifestations, which creates an urgent need to study its causes and develop safe, effective and affordable treatment methods. The purpose of this work was to analyze scientific data on the effect of fat-soluble antioxidant vitamins on human reproductive function and to as-sess the prospects of antioxidant therapy in the treatment of female and male infertility. Material and Methods. The PRISMA principle was used to search and select articles. The search for publications for review was carried out in the Cochrane databases (Cochrane Group on Gynecology and Infertility Treatment (CGF), MedLine (PubMEd), ScienceDirect (Elsevier), as well as the Russian scientific electronic library eLibrary.Ru, including neurosearch. Results. Study of the functional state Numerous studies have been devoted to the human reproductive system in conditions of deficiency of fat-soluble vitamins and antioxidants, during which the relationship between the content of carotenoids, retinol, α-tocopherol and other fat-soluble antioxi-dants in the blood of women and men and reproductive dysfunction has been identified. An analysis and synthesis of published clinical studies has been carried out. on the influence of fat-soluble antioxidant vitamins on the human reproductive system, and it has been established that the pro-spects for antioxidant therapy in the treatment of infertility are being investigated, while focusing on the deficiency of antioxidants, in particular vita-mins A, E, D and carotenoids, as a significant factor causing reproductive dysfunction systems. Their role and potential impact on improving the repro-ductive health of men and women is discussed. Conclusions. The lack of representation of antioxidant therapy regimens in standard clinical guidelines for the treatment of female and male infertility is due to the current lack of evidence of adequate quality confirming its effectiveness and safety. In this regard, the need to design and conduct high-quality randomized placebo-controlled clinical trials to determine the effectiveness and safety of antioxidant therapy in the treatment of infertility is emphasized.