DIRECT ORAL ANTICOAGULANTS PRESCRIPTION IN THE ELDERLY: PREDICTORS OF ADVERSE OUTCOMES

Introduction. Due to the increasing number of geriatric patients, there is a need to improve the results of direct oral anticoagulants (POAC) use in this group – increasing the safety of drug administration, evaluation of predictors of POAC-dependent complications. Aim – to report on possible predictors of adverse outcomes of oral anticoagulants (POACs) in the elderly. Material and Methods. The study included 272 elderly patients with C3a-C4 chronic kidney disease (CKD). We evaluated POAC intake violation, as well as complications, their relation to the facts obtained by questionnaire and laboratory methods of investigation. Results. The main POAK-dependent complication was "minor bleeding", which in some cases led to drug withdrawal (which could increase the risk of thromboembolic complications), however, independent drug withdrawal was quite rare and was not a reliable predictor of adverse outcomes. Neverthe-less, the incidence of nosebleeds was correlated with serum creatinine level, CKF, and arterial hypertension. Apixaban was associated with a lower in-cidence of complications per analysis. Conclusion. Complications per assay associated with POAC administration were more common with an ICF below 45 mL/min. Serum creatinine, stage of CKD and degree of arterial hypertension are parameters whose control may reduce the incidence of POAC-dependent complications