Association of glucagon-like peptide-1 receptor agonists with atrial fibrillation, cardiac arrest, and ventricular fibrillation: Casual evidence from a drug target Mendelian randomization
Our findings suggest that genetically proxied GLP-1RAs are causally associated with a reduced risk of AF, cardiac arrest, and ventricular fibrillation. Further randomized controlled trials are needed to confirm these results.
Authors
- Jitao Ling (ORCID: https://orcid.org/0000-0002-1720-8620)
- Miao Yan (ORCID: https://orcid.org/0000-0001-6440-4686)
- Ziheng Zheng (ORCID: https://orcid.org/0009-0004-9240-3751)
- Xiao Liu (ORCID: https://orcid.org/0000-0001-8252-3435)
- Xinyi Zhang (ORCID: https://orcid.org/0000-0002-3173-0589)
- Xiaoyue Zhang (ORCID: https://orcid.org/0009-0006-7038-8583)
- Yuting Wu (ORCID: https://orcid.org/0000-0002-9133-2144)
- Jing Zhang (ORCID: https://orcid.org/0000-0001-9490-2352)
- Wenli Gu (ORCID: https://orcid.org/0000-0002-9964-8805)
- Peng Yu (ORCID: https://orcid.org/0009-0009-7553-6380)
- Chen Li (ORCID: https://orcid.org/0009-0002-0935-9557)
- Nan‐Jing Peng
- Zicheng Zhu
- Abudukeremu Ayiguli
Institutions
- Nanchang University (CN)
- Sun Yat-sen University (CN)
- Guangxi Medical University (CN)
- Queen Mary Hospital (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Duke-NUS Medical School (SG)
- University of Hong Kong (HK)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1186/s13098-025-01712-w
- Citations
- 4
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 5.18
Funders
- National Natural Science Foundation of China