Alterations in gene expression associated with invasion of RAS-mutant thyroid tumors and their potential diagnostic and therapeutic utility
Development of invasion in RAS-mutant tumors is associated with significant alteration in gene expression. Expression levels of six genes and nodule size may predict invasion in RAS-mutant thyroid nodules, whereas chemical inhibition of CA12 may have a potential therapeutic effect in RAS-mutant tumors.
Authors
- Daniel M. Spagnolo
- Yuri E. Nikiforov (ORCID: https://orcid.org/0000-0002-2239-1095)
- Marina N. Nikiforova (ORCID: https://orcid.org/0000-0001-9976-9378)
- William R Doerfler
- G Schmidt (ORCID: https://orcid.org/0000-0001-9265-2484)
- Vincenzo Condello (ORCID: https://orcid.org/0000-0003-4569-5398)
- Alyaksandr V. Nikitski (ORCID: https://orcid.org/0000-0001-6486-667X)
- Abigail I. Wald (ORCID: https://orcid.org/0000-0003-0621-5312)
- Ian J. Fornal
Institutions
- University of Pittsburgh (US)
Publication Details
- Journal
- European Thyroid Journal
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1530/etj-25-0022
- Citations
- 4
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.18