Enhancement of Dissolution Rate of Fenofibrate By Using Liqui-solid Technique

Fibrates have played a major role in the treatment of hyperlipidemia for more than two decades (Miller and Spence 1998). The first member of this class, clofibrate, was identified in 1962 by Thorp and Waring (1962) and became available in the US in 1967. The third-generation fibric acid derivative Fenofibrate was synthesized in 1975 and was introduced. Drugs with poor wetting, slow dissolution properties, optimum absorption high in GIT may be difficult to formulate or manufacture as a tablet that will still provide adequate or full drug bioavailability. To enhance these properties like absorption, dissolution which are rate limiting step for lipophilic or poorly soluble drugs, the “Liquisolid Technique” was introduced. It is the most promising & novel techniques to improve the dissolution rates of the poorly water soluble drugs.