Interferon-γ Therapy in Patients With Refractory Disseminated Coccidioidomycosis
Refractory disseminated coccidioidomycosis (DCM) is a severe disease with limited treatment options. This report reviews our own and prior published experiences using adjunctive interferon-γ therapy in refractory DCM, showing overall favorable responses in patients without signal transducer and activator of transcription 1 gain-of-function mutations.
Authors
- Eva Le Run
- Rajarshi Ghosh (ORCID: https://orcid.org/0000-0002-5780-8241)
- Amy P. Hsu (ORCID: https://orcid.org/0000-0001-6841-2122)
- Brenna LaBere (ORCID: https://orcid.org/0000-0002-7967-7270)
- Atl Simon Arias Rivera (ORCID: https://orcid.org/0000-0002-5495-194X)
- Lavenda Chirombo Kluczynski
- Andrew J. Oler (ORCID: https://orcid.org/0000-0002-6310-0434)
- Annalie J Harris (ORCID: https://orcid.org/0009-0007-8231-8002)
- Scott Ostdiek
- John K. De Witt
- Nicolas Barros (ORCID: https://orcid.org/0000-0002-8531-3537)
- James K. Woodward
- L. Joseph Wheat
- Chen Wang (ORCID: https://orcid.org/0000-0003-4055-7391)
- Michell Lozano Chinga (ORCID: https://orcid.org/0000-0002-9204-702X)
- Victoria Anderson
- Steven M. Holland (ORCID: https://orcid.org/0000-0003-3207-5464)
- Alexandra F. Freeman (ORCID: https://orcid.org/0000-0001-7005-8345)
- Magdalena Walkiewicz
- Wassim Ballan (ORCID: https://orcid.org/0000-0003-2197-8211)
- Matthew W Smith
- Morgan N. Similuk (ORCID: https://orcid.org/0000-0002-0403-2689)
- Keith A. Sacco (ORCID: https://orcid.org/0000-0001-8189-7769)
- Christa S. Zerbe (ORCID: https://orcid.org/0000-0003-4219-0503)
- Fariba Donovan (ORCID: https://orcid.org/0000-0002-6203-5693)
- Cindy Palmer
- Lindsey B Rosen
- Jennifer Daub (ORCID: https://orcid.org/0000-0001-6022-563X)
- John N. Galgiani (ORCID: https://orcid.org/0000-0002-7882-1883)
Institutions
- Indiana Department of Natural Resources (US)
- National Institutes of Health (US)
- University of Arizona (US)
- Barts Health NHS Trust (GB)
- Royal London Hospital (GB)
- Phoenix Children's Hospital (US)
- National Institute of Allergy and Infectious Diseases (US)
- BIO5 Institute
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1093/cid/ciaf286
- Citations
- 3
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- NHLBI Division of Intramural Research