PROCESSING FACTORS AFFECTING THE PROPERTIES OF SPHERICAL AGGLOMERATES

Spherical agglomerates, formed through a particle engineering technique known as spherical crystallization, are crucial in pharmaceutical industry.This review explores the key factors and operational parameters affecting the properties of spherical agglomerates, with a focus on their impact in pharmaceutical applications.The judicious choice of solvent addition methods, bridging liquids, and agitation temperatures significantly impacts agglomerate size, morphology, surface texture, and dissolution rates.These properties have a direct bearing on the efficiency of drug delivery systems.Furthermore, mechanical properties, thereby affecting the flow properties and compressibility of agglomerates, which are critical for tablet manufacturing have also been discussed.Nuclei formation, consolidation, coalescence, and layering are integral processes that allow for the customization of agglomerate properties.Control over these factors is imperative for tailoring agglomerates to meet specific product requirements, ensuring efficient drug delivery, consistent product quality, and controlled drug release.