Predicting and preventing Alzheimer’s disease

With all the advances in both the science of aging and artificial intelligence (AI), we are in a propitious position to accurately and precisely determine who is at high risk of developing Alzheimer's disease years before signs of even mild cognitive deficit. It takes at least 20 years for aggregates of misfolded β-amyloid and tau proteins to accumulate in the brain along with neuroinflammation that they incite. This provides a long window of opportunity to get ahead of the pathobiological process, both for prediction and prevention.

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Publication Details

Journal
Science
Published
2025-05-29
DOI
https://doi.org/10.1126/science.ady3217
Citations
9
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
10.48
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article

Predicting and preventing Alzheimer’s disease

Eric J. Topol
9 citations
Science
Alzheimer's disease research and treatments
10.48
article

Predicting and preventing Alzheimer’s disease

Eric J. Topol
article en
9 citations

Abstract

With all the advances in both the science of aging and artificial intelligence (AI), we are in a propitious position to accurately and precisely determine who is at high risk of developing Alzheimer's disease years before signs of even mild cognitive deficit. It takes at least 20 years for aggregates of misfolded β-amyloid and tau proteins to accumulate in the brain along with neuroinflammation that they incite. This provides a long window of opportunity to get ahead of the pathobiological process, both for prediction and prevention.

ScienceVol. 388(6750)
Scripps Research Institute (US)
Openalex Percentile: Top 2%
Alzheimer's disease research and treatments
10.48
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Predicting and preventing Alzheimer’s disease — Eric J. Topol · Science (2025) | TGRS Research Map | TGRS