The diagnosis of GH deficiency in adult β-thalassemic patients: are two different stimulation tests necessary to improve specificity?
The marked variability in GHD diagnoses among adult patients with βTM highlights the need for multiple diagnostic tests to improve accuracy and avoid unnecessary interventions. Our findings highlight the importance of reassessing GH secretory reserves with multiple tests at multiple time points, supporting a cautious approach to hormone replacement therapy, suggesting to start it only when clearly indicated.
Authors
- Emanuela D’Angelo (ORCID: https://orcid.org/0000-0003-4763-8725)
- Elena Cassinerio (ORCID: https://orcid.org/0000-0003-4392-5225)
- Riccardo Pasquali
- Massimo Scacchi (ORCID: https://orcid.org/0000-0002-4624-9114)
- Leila Danesi
- Daniele Sola (ORCID: https://orcid.org/0000-0001-7863-8192)
- Giovanna Graziadei (ORCID: https://orcid.org/0000-0002-6801-5730)
- M. Daniele
- Nadia Mirra
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Ospedale San Giuseppe (IT)
- European Institute of Oncology (IT)
Publication Details
- Journal
- Pituitary
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1007/s11102-025-01540-1
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute