GPR56/ADGRG1 induces biased Rho-ROCK-MLC and JAK-STAT3 signaling to promote amoeboid-like morphology and IL-6 upregulation in melanoma cells
Our findings reveal complex GPR56-mediated biased signaling through the Rho-ROCK-MLC and JAK-STAT3 pathways, highlighting these networks as potential therapeutic targets for modulating distinct tumorigenic phenotypes in human melanoma cells.
Authors
- Tse‐Ching Chen (ORCID: https://orcid.org/0000-0003-2532-7328)
- Martin Stacey (ORCID: https://orcid.org/0000-0003-3502-5542)
- I Kuan-Yu
- Kuan‐Yeh Huang
- Ya‐Fang Chiu (ORCID: https://orcid.org/0000-0002-7506-9032)
- Chuan‐Mao Hung
- Kwai‐Fong Ng
- Yu‐Chi Chang (ORCID: https://orcid.org/0000-0002-1808-2732)
- Hsin‐Yi Chen (ORCID: https://orcid.org/0000-0003-3810-4860)
- Hsi-Hsien Lin
- Wan-Chen Yu
Institutions
- University of Leeds (GB)
- Chang Gung University (TW)
- Chang Gung Memorial Hospital (TW)
- Daiseung Medics (South Korea) (KR)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1186/s12964-025-02267-z
- Citations
- 2
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Chang Gung Memorial Hospital, Linkou