Childhood Humoral Immunity During and After COVID-19 Lockdowns
Our study, including serum from 3678 hospital inpatients and outpatients sampled before, during and after the COVID-19 lockdown periods, showed a significant decrease in overall IgG levels during the periods of sanitary restriction, particularly in children 3-10 years of age. Few months after the lifting of COVID-19 restrictions, immunoglobulin levels normalized. COVID-19 lockdowns may have induced a transient humoral immune gap.
Authors
- Isabelle Pellier (ORCID: https://orcid.org/0000-0002-7988-4712)
- Julien Lejeune (ORCID: https://orcid.org/0000-0002-3862-9475)
- Charline Miot (ORCID: https://orcid.org/0000-0002-4586-1061)
- Coralie Mallebranche (ORCID: https://orcid.org/0000-0002-8385-4057)
- V. Giacobbi
- Marie‐Alexandra Alyanakian (ORCID: https://orcid.org/0000-0002-9902-9027)
- Emeline Vinatier (ORCID: https://orcid.org/0000-0002-7481-2779)
- Céline Beauvillain (ORCID: https://orcid.org/0000-0002-6987-3120)
- Tiffanie Bousser
Institutions
- Hôpital Necker-Enfants Malades (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre Hospitalier Universitaire d'Angers (FR)
- Centre Hospitalier du Mans (FR)
- Thion Medical (France) (FR)
- Université d'Angers (FR)
- Nantes Université (FR)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1097/inf.0000000000004869
- Citations
- 2
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 2.71