Geranylgeranyl Pyrophosphate Promotes Hepatic Lipid Accumulation by Prenylation of Perilipin4
Hepatic GGPP drives MUO progression by facilitating Perilipin4 prenylation, thereby promoting pathological lipid droplet expansion and insulin resistance. Targeting GGPP with inhibitors of GGPPS like DGBP represents a promising strategy for treating MUO. These findings provide novel insights into the metabolic heterogeneity of obesity and potential therapeutic interventions for MUO-related complications.
Authors
- Jingzi Zhang (ORCID: https://orcid.org/0000-0002-7190-6243)
- Yiping Tang (ORCID: https://orcid.org/0000-0001-7007-2630)
- Shan Jiang (ORCID: https://orcid.org/0000-0002-3467-8640)
- Peng Sun (ORCID: https://orcid.org/0000-0003-3811-0371)
- Hong-Yu Nie
- Mengfei Zhao
- Xiao Han (ORCID: https://orcid.org/0000-0001-9262-7254)
- Xiaodong Shan
- Lei Fang (ORCID: https://orcid.org/0000-0002-2582-4845)
- Xiao-Chen Wang (ORCID: https://orcid.org/0000-0001-8931-0846)
- Jian He (ORCID: https://orcid.org/0000-0002-7906-4132)
- Yue Zhao (ORCID: https://orcid.org/0000-0003-2869-5257)
- Chaojun Li (ORCID: https://orcid.org/0000-0001-9474-7321)
- Xitai Sun (ORCID: https://orcid.org/0000-0001-9679-0171)
- Xianwen Yuan
- Yan Bi
- Ming Zou
- Jiang-Huai Liu
Institutions
- Nanjing Drum Tower Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101546
- Primary Topic
- Lipid metabolism and biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities