Targeting BATF2-RGS2 axis reduces T-cell exhaustion and restores anti-tumor immunity
RGS2, regulated by BATF2, plays a critical role in driving T cell exhaustion and tumor immune evasion in LC. Targeting the BATF2-RGS2 axis may enhance the effectiveness of immunotherapy by reversing T cell exhaustion and improving anti-tumor immunity.
Authors
- Deping Zhao (ORCID: https://orcid.org/0000-0003-0109-5171)
- Xuyu Gu (ORCID: https://orcid.org/0000-0001-7739-5301)
- Wentian Zhang (ORCID: https://orcid.org/0000-0003-3332-0476)
- Chanchan Gao (ORCID: https://orcid.org/0000-0001-7243-8659)
- Qiyu Fang (ORCID: https://orcid.org/0000-0002-7001-143X)
- Ziming Wang (ORCID: https://orcid.org/0000-0002-3532-8642)
- Yaoyao Zhu (ORCID: https://orcid.org/0009-0008-4943-608X)
- Jia Yu (ORCID: https://orcid.org/0000-0002-4481-2022)
- Xiangyu Su
Institutions
- Zhongda Hospital Southeast University (CN)
- Shanghai Pulmonary Hospital (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s12943-025-02351-5
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05