IFN-α and vitamin B6-induced galectin-9 promotes the immunomodulatory function of human clonal mesenchymal stem cells
This novel combination of priming factors significantly promotes the immunomodulatory functions of cMSCs by inducing Gal-9. Consequently, Gal-9 may serve as an excellent biomarker for screening primed cMSCs for their immunomodulatory capabilities, facilitating a more accurate assessment of their therapeutic effectiveness.
Authors
- Yunok Park
- Jin‐Min Nam (ORCID: https://orcid.org/0000-0001-6917-3688)
- Byeol Choi
- Geun‐Hyung Kang
- Tiffany S. Ko (ORCID: https://orcid.org/0000-0002-5113-0310)
- Jeong Hyun Moon (ORCID: https://orcid.org/0000-0002-2463-8944)
- Donghee Shin (ORCID: https://orcid.org/0000-0002-5439-4493)
- Si-Na Kim
- Myung‐Shin Jeon (ORCID: https://orcid.org/0000-0003-2681-8735)
- Seyeon Park (ORCID: https://orcid.org/0000-0002-2471-3174)
- Younghun Jung (ORCID: https://orcid.org/0000-0003-4718-2270)
- Yun-Kyoung Cho
Institutions
- Inha University (KR)
- Inha University Hospital (KR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s13287-025-04394-3
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Inha University
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- Inha University Hospital