The mechanism of telomerase Cajal body protein 1 regulating senescence of mouse bone marrow mesenchymal stem cells
Transcriptome sequencing suggests that the mechanism of TCAB1 inhibiting BMSC senescence is related to cell cycle and metabolic process, and exerts anti-BMSC senescence function by regulating the expression of key factors Slc2a1 and Egln3. This study confirmed that the expression of TCAB1 is closely related to the senescence of BMSC through molecular level, which provides a new technique for the clinical treatment of cell senescence.
Authors
- Xilong Zhao (ORCID: https://orcid.org/0000-0002-5182-9180)
- Xinghua Pan (ORCID: https://orcid.org/0000-0002-7421-8155)
- Zi‐An Li (ORCID: https://orcid.org/0000-0002-6338-8933)
- Nini Tian
- Guang‐Ping Ruan (ORCID: https://orcid.org/0000-0002-3784-7040)
- Xiang Yao (ORCID: https://orcid.org/0000-0002-9948-3879)
- Qiang Wang (ORCID: https://orcid.org/0000-0002-3079-6383)
- Shuqian Lin
- Jin Gao (ORCID: https://orcid.org/0000-0002-9305-3907)
Institutions
- Yunnan University (CN)
- Kunming Medical University (CN)
- Yunnan Observatories (CN)
- First People's Hospital of Yunnan Province (CN)
- Cell Technology (China) (HK)
- The First Hospital of Kunming (CN)
- Yunnan Machinery Research and Design Institute (CN)
- Yunnan Province Science and Technology Department (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s13287-025-04406-2
- Citations
- 1
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 1.16