The regulatory variant rs1950834 confers the risk of depressive disorder by reducing LRFN5 expression
These findings reveal that the functional risk single nucleotide polymorphism rs1950834 at 14q21.1 regulates LRNN5 expression and function in NAc, providing a novel perspective for molecular diagnosis and targeted interventions of MDD.
Authors
- Aini Zhang (ORCID: https://orcid.org/0000-0002-4009-0595)
- Di Luan (ORCID: https://orcid.org/0000-0002-8832-7555)
- Xiong‐Jian Luo (ORCID: https://orcid.org/0000-0003-2543-8845)
- Xi Chen (ORCID: https://orcid.org/0000-0002-5807-4219)
- Qingqing Bai
- Yan Kong (ORCID: https://orcid.org/0000-0002-2266-7872)
- Xinglun Dang
- Shaolei Jiang
- Yifan Li (ORCID: https://orcid.org/0000-0001-7790-4524)
- Junyang Wang (ORCID: https://orcid.org/0009-0007-5285-4744)
- Yingjie Zhu
- Te Zhao
- Zhijun Zhang (ORCID: https://orcid.org/0000-0003-4538-8187)
- Yun Sun
Institutions
- University of Shanghai for Science and Technology (CN)
- Kunming Medical University (CN)
- Zhengzhou University (CN)
- Ministry of Education (CL)
- Shenzhen Institutes of Advanced Technology (CN)
- Southeast University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s12916-025-04141-8
- Citations
- 2
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 1.91
Funders
- National Natural Science Foundation of China