Cell-free fat extract prevents diminished ovarian reserve by inhibiting granulosa cell senescence
Early prophylactic administration of CEFFE in adult mice can prevent DOR and extend their reproductive lifespan by inhibiting granulosa cell senescence.
Authors
- Xiaowei Zhou
- Huaming Zhu (ORCID: https://orcid.org/0000-0002-1827-0557)
- Jingru Duan (ORCID: https://orcid.org/0009-0006-8232-5854)
- Mengyu Liu (ORCID: https://orcid.org/0000-0002-0568-1787)
- Aijun Zhang (ORCID: https://orcid.org/0000-0003-2879-9961)
- Yuhong Shen
Institutions
- Shanghai Jiao Tong University (CN)
- Peking University (CN)
- Ruijin Hospital (CN)
- Institut de Médecine de la Reproduction (FR)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s13287-025-04383-6
- Citations
- 2
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- National Natural Science Foundation of China
- Key Technologies Research and Development Program