Role of BAZ2A in Cervical Cancer and Its Effect on Tumor Cell Metabolism

This study aims to investigate the role of BAZ2A in cervical cancer and its relationship with cancer development and glycolipid metabolism. BAZ2A knockdown experiments were performed in HeLa cells to study its effects on cell proliferation, invasion, cloning and migration; transcriptome and metabolome sequencing were also performed, and differentially expressed genes and metabolites were analyzed by GO and KEGG enrichment, etc. BAZ2A is highly expressed in cervical cancer, and the knockdown of BAZ2A inhibits the related malignant behaviors in HeLa cells. Transcriptome analysis identified a large number of differentially - expressed genes and related pathways, while metabolome analysis identified a variety of different metabolites and related pathways. The joint analysis revealed that key genes and metabolites are involved in the BAZ2A regulatory network, affecting the related signaling pathways. Moreover, BAZ2A plays an important role in cervical cancer development and is closely related to glycolipid metabolism. In conclusion, BAZ2A affects cervical cancer development via cell proliferation, cloning, migration, invasion, and energy metabolism.