Outcomes of chemotherapy with or without immunotherapy in older patients with non-small cell lung cancer and low PD-L1 expression
ICI combined with chemotherapy may be a potentially effective treatment strategy for older patients with NSCLC and low PD-L1 expression. However, compared with the overall population, the benefits of adding ICI to chemotherapy were decreased, while the risk of toxicity may increase, making appropriate patient selection crucial for this population. Particularly, in patients with ECOG PS 1, the additional benefit of ICI over chemotherapy was minimal in terms of efficacy, suggesting that the introduction of ICI combined with chemotherapy should be carefully considered for this patient population.
Authors
- Satoshi Watanabe (ORCID: https://orcid.org/0000-0003-0041-6981)
- Yasuhiro Gotô (ORCID: https://orcid.org/0000-0003-2235-8567)
- Akihiro Yoshimura (ORCID: https://orcid.org/0000-0002-3753-2110)
- Tomoya Fukui (ORCID: https://orcid.org/0000-0003-4814-4401)
- Akira Nakao (ORCID: https://orcid.org/0000-0001-8308-4227)
- Takashi Kijima (ORCID: https://orcid.org/0000-0003-4249-4021)
- Shinsuke Shiotsu (ORCID: https://orcid.org/0000-0002-7195-0770)
- Asuka Okada (ORCID: https://orcid.org/0000-0001-5854-2257)
- Yusuke Chihara (ORCID: https://orcid.org/0000-0002-7533-844X)
- Hirokazu Taniguchi (ORCID: https://orcid.org/0000-0003-2414-8344)
- Kyoichi Kaira (ORCID: https://orcid.org/0000-0001-5548-7686)
- Koichi Takayama (ORCID: https://orcid.org/0000-0002-7723-8960)
- Keiko Tanimura (ORCID: https://orcid.org/0000-0002-7826-4466)
- Tae Hata (ORCID: https://orcid.org/0000-0002-0598-2280)
- Makoto Hibino (ORCID: https://orcid.org/0000-0002-1638-5027)
- Yoshiki Negi
- Hayato Kawachi (ORCID: https://orcid.org/0000-0002-1673-2260)
- Naoki Furuya (ORCID: https://orcid.org/0000-0001-7162-5946)
- Tadaaki Yamada (ORCID: https://orcid.org/0000-0002-6945-281X)
- Tomohiro Oba
- Tatsuki Ikoma (ORCID: https://orcid.org/0000-0003-3758-3425)
- Akihiko Amano
- Daiki Murata (ORCID: https://orcid.org/0000-0002-4295-5046)
Institutions
- Kurume University (JP)
- Kansai Medical University (JP)
- Fujita Health University (JP)
- St. Marianna University School of Medicine (JP)
- Kyoto Prefectural University of Medicine (JP)
- Kurashiki Central Hospital (JP)
- Fukuoka University Hospital (JP)
- Saiseikai Suita Hospital (JP)
- Kyoto first Red Cross hospital (JP)
- Saitama Red Cross Hospital (JP)
- Japanese Red Cross Society Kyoto Daini Hospital (JP)
- Nagasaki University (JP)
- Niigata University (JP)
- Saitama Medical University (JP)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2025-05-01
- DOI
- https://doi.org/10.21037/tlcr-2024-1236
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05