Impaired natural killer cell maturation in lung adenocarcinoma driven by FABP4 and SPON2 downregulation through disrupted lipid metabolism
The study findings present new evidence showing that low <i>FABP4</i> and <i>SPON2</i> gene expression may impair NK cell maturity by affecting lipid metabolism in lung adenocarcinoma. These results provide a new perspective on restoring immune function in patients with lung cancer.
Authors
- Shuilian Zhang
- Kezhen Li (ORCID: https://orcid.org/0000-0001-7943-5389)
- Zhi Xie (ORCID: https://orcid.org/0000-0002-5589-4836)
- Xin Huang (ORCID: https://orcid.org/0000-0001-8584-0284)
- Wen‐Zhao Zhong (ORCID: https://orcid.org/0000-0002-8917-8635)
- Jing Chen (ORCID: https://orcid.org/0000-0002-9207-8192)
- Si-Pei Wu (ORCID: https://orcid.org/0000-0002-8335-0342)
- Hong‐Xia Tian (ORCID: https://orcid.org/0000-0003-3964-7947)
- Zepeng Guo
- Wei‐Bang Guo
Institutions
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2025-05-01
- DOI
- https://doi.org/10.21037/tlcr-24-1027
- Citations
- 1
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94