Oral microbiome and risk of lung cancer: results from a two-sample mendelian randomization analysis

The oral microbiomes, <i>Gemella haemolysans</i> (pheno.388) from saliva, an unclassified species (pheno.844) of Clostridia from saliva and an unclassified species (pheno.1354) of <i>Prevotella</i> from tongue, were causally associated with lung cancer. Oral microbiology holds significant potential for clinical applications in etiologic exploration, early screening, prevention, and enhancing survival in lung cancer. Regarding treatment, personalized therapy based on oral flora may provide novel therapeutic strategies for lung cancer.