Associations of Serum Omega-6 Polyunsaturated Fatty Acids With Biomarkers of Inflammation

Objectives: Observational evidence supports associations between higher intakes of omega-6 (n-6) polyunsaturated fatty acids (PUFA) and reduced risks for cardiometabolic diseases. However, some have hypothesized that higher n-6 PUFA intake may be pro-inflammatory. It is known that serum levels of total n-6 PUFA and linoleic acid (LA), the predominant dietary n-6 PUFA, correlate with dietary LA intake. The purpose of this cross-sectional analysis using baseline data from the Aegis cohort was to examine associations of serum LA and total n-6 PUFA levels with biomarkers of inflammation.