Clinical significance of urine-based automated detection of GSTP1 methylation for the diagnosis of suspected prostate cancer patients
Automated detection of urinary GSTP1 methylation significantly enhanced PCa diagnostic value, outperforming PSA in sensitivity, specificity, and accuracy. Combining urinary GSTP1 methylation with PSA notably improved accuracy, especially in the PSA gray zone (4.0-10.0 ng/mL), demonstrating excellent efficacy. This non-invasive, easily performed method showed high diagnostic efficacy, indicating strong clinical potential.
Authors
- Yaping Xing
- Ruidong Ji (ORCID: https://orcid.org/0000-0003-0641-5891)
- Zhenquan Lu
- Yifei Zhu (ORCID: https://orcid.org/0000-0002-9153-0175)
- Mingchi Wang
- Keya Mao (ORCID: https://orcid.org/0000-0003-4734-5228)
- Liang Zhang (ORCID: https://orcid.org/0000-0002-9463-3241)
- Yang Yu (ORCID: https://orcid.org/0000-0002-5512-3396)
- Bingfeng Luo (ORCID: https://orcid.org/0000-0002-3604-4270)
- Richard Hoau Gong Lo
Institutions
- University of Hong Kong - Shenzhen Hospital (CN)
- Guangdong Province Women and Children Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Translational Andrology and Urology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.21037/tau-2024-689
- Citations
- 2
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 3.04