Fisetin-mediated PPAR-γ upregulation: a novel therapeutic approach for corpus cavernosum smooth-muscle-cell apoptosis and restoration of erectile function after cavernous nerve injury
Fisetin may exert a protective effect against CNI-induced apoptosis in CCSMCs, ameliorate the fibrosis of the corporal tissue, and enhance EF, primarily through the upregulation of PPAR-γ expression.
Authors
- Runnan Xu (ORCID: https://orcid.org/0009-0009-3270-0988)
- Xin Zhang (ORCID: https://orcid.org/0000-0001-6822-3268)
- Yijia Fu (ORCID: https://orcid.org/0009-0008-5308-1373)
- Bodong Lv (ORCID: https://orcid.org/0000-0002-3953-5753)
Institutions
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Translational Andrology and Urology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.21037/tau-2025-63
- Primary Topic
- Acupuncture Treatment Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00