Risk Factors of central-line associated bloodstream infections among adult patients on parenteral nutrition

Central venous catheter is preferred for the administraon of parenteral nutrion (PN) as it allows longer period of use and higher osmolarity cutoff.However, one of the common complicaons is central-line associated bloodstream infecon, which increases mortality and healthcare burden.This study aimed to determine the prevalence and risk factors of centralline associated bloodstream infecon among adult paents on parenteral nutrion.This was a retrospecve study involving all adult paents at Hospital Queen Elizabeth, Sabah who received parenteral nutrion via central venous catheter from 1 April 2022 to 31 March 2023.Potenal risk factors of central-line associated bloodstream infecon were idenfied from medical records.The infecon prevalence was calculated and associated risk factors were determined using mulple logisc regression.Of 112 paents, more than half were male (n=70, 62.5%) with mean age of 53.415.1.Majority of the paents were from surgical ward (n=61, 61.6%), followed by intensive care unit (n=25, 22.3%).Central-line associated bloodstream infecon was present in 25 paents (22.3%).The median PN duraon was nine days (interquarle range=5-19).Duraon of parenteral nutrion was the only factor demonstrang stascally significant associaon with central-line associated bloodstream infecon (adjusted odds rao=1.08;95% confidence interval=1.03-1.13;p=0.001).Approximately a quarter of paents in our study developed central-line associated bloodstream infecon.Longer duraon of parenteral nutrion indicates longer catheterisaon which exposes paents to higher risk of infecon, potenally via catheter manipulaon or infusate contaminaon.Prospecve studies should be considered in future to explore strategies in reducing the infecon occurrence.