Clinical course and outcomes of supravalvular aortic stenosis in adults
In adulthood, SVAS patients showed a stable clinical course without rapid progression. While cardiovascular events occurred in this young cohort, they were mostly obsereved in those with additional congenital heart defects, suggesting a more optimistic view for SVAS itself. No significant differences in outcomes were observed in patients with/without Williams-Beuren syndrome. Overall, SVAS tends to follow a more benign course in adulthood compared with childhood, potentially allowing for less intensive follow-up- though follow-up should still be individualised based on associated congenital heart defects and cardiovascular risks.
Authors
- Jolien W. Roos‐Hesselink (ORCID: https://orcid.org/0000-0002-6770-3830)
- Monique R.M. Jongbloed
- Roland R L van Kimmenade
- Zoë A Keuning
- Berto J. Bouma (ORCID: https://orcid.org/0000-0002-1433-9692)
- Adine R de Keijzer (ORCID: https://orcid.org/0009-0007-9903-5324)
- Jolanda Kluin (ORCID: https://orcid.org/0000-0002-5942-4727)
- Frederike Meccanici (ORCID: https://orcid.org/0000-0003-3244-8195)
- Annemien E. van den Bosch (ORCID: https://orcid.org/0000-0002-0422-9860)
- Joost P van Melle (ORCID: https://orcid.org/0000-0002-4282-4628)
- Michiel Voskuil (ORCID: https://orcid.org/0000-0003-1789-8462)
Institutions
- Leiden University (NL)
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- ERN GUARD-Heart (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Open Heart
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1136/openhrt-2025-003355
- Primary Topic
- Williams Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Heart Foundation