Diagnostic value of fluid‐based non‐amyloid biomarkers for Alzheimer's disease and related dementias in a clinic‐based cohort from South Asia
Serum glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) levels were significantly greater in patients with dementia than in healthy controls.Significant correlation was observed between the serum and cerebrospinal fluid levels of GFAP, NfL, and total tau independent of the baseline demographics or co-morbidities, indicating their potential role in clinical practice.Serum biomarker levels were related to the severity of dementia.This is one of few studies on fluid-based biomarkers in diverse cohorts with Alzheimer's disease and related dementias in the South Asian cohort with limited resources.
Authors
- Suvarna Alladi (ORCID: https://orcid.org/0000-0002-0372-9572)
- Rose Dawn Bharath (ORCID: https://orcid.org/0000-0002-7464-4250)
- Ravi Girikematha Shankar (ORCID: https://orcid.org/0000-0002-4970-6173)
- Paras Rohidas Borse
- B. H. Gagantej
- Sarada Subramanian
- Subasree Ramakrishnan (ORCID: https://orcid.org/0000-0001-7659-6531)
- M. M. Samim
- Pooja Mailankody
- Faheem Arshad
Institutions
- National Institute of Mental Health and Neurosciences (IN)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/dad2.70129
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Science and Engineering Research Board